NANOPROFILING LTD
Innovative microscopes for electrochemical analysis
Nanoprofiling LTD is a young company, whose activities are focused on the development of innovative electrochemical nanoprobes for local electrochemical analysis, in particular, ion-conducting microscopes.
The company develops biophysical and electrophysiological scanning methods that are of particular value for various types of research.
The company develops biophysical and electrophysiological scanning methods that are of particular value for various types of research.
Disk-shaped carbon nanoelectrodes embedded into quartz nanopipette and platinum electrodes deposited at the tip of carbon electrodes. Tip size ≤ 150 nm. Diameter at the back end of the pipette is 0.5 mm that provides easy access for electrical connection using thin metal wire.
Electrodes Applications:
Electrodes can be used for neurotransmitter release detection, and also as a base for subsequent deposition/surface modification with materials/molecules of interest to form selective nanoprobes for example for intracellular detection of reactive oxygen species (ROS).
Electrodes
Double Barrel electrodes
Double barrel quartz pipette with none, one or both barrels filled with electrically conductive carbon. Tip diameter ≤ 200 nm.
Electrodes Applications:
Double barrel electrodes can be used for simultaneous topographical and electrochemical imaging (SICM-SECM).
In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species
In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs.
The main advantages of this method are the short incubation time with the drug, and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time.
The main advantages of this method are the short incubation time with the drug, and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time.
Nanoprofiling Limited
The Fisheries, 1 Mentmore Terrace, London, England, E8 3PN
Phone:
E-mail:
Phone:
E-mail:
Directors
Sir Christopher Edwards
Professor Yuri Korchev
Sir Christopher Edwards
Professor Yuri Korchev
1.Joanna Bednarska, Annegret Pelchen Matthews, Pavel Novak, Jemima J.Burden, Peter A. Summers, Marina K. Kuimova, Yuri Korchev, Mark Marsh, Andrew Shevchuk, Rapid formation of human immunodeficiency virus-like particles. Proceedings of the National Academy of Sciences, 117 (35) 21637-21646 (2020)
2. Pamela Swiatlowska, Jose L. Sanchez-Alonso, Catherine Mansfield, Denis Scaini, Yuri Korchev, Pavel Novak and Julia Gorelik, Short-term angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications. Nanoscale, 12, 16315-16329 (2020)
3. Alexander N. Vaneev, Petr V. Gorelkin, Anastasiia S. Garanina, Helena V. Lopatukhina, Stepan S. Vodopyanov, Anna V. Alova, Oxana O. Ryabaya, Roman A. Akasov, Yanjun Zhang, Pavel Novak, Sergey V. Salikhov, Maxim A. Abakumov, Yasufumi Takahashi, Christopher R. W. Edwards, Natalia L. Klyachko, Alexander G. Majouga, Yuri E. Korchev, and Alexander S. Erofeev, In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs. Analytical Chemistry 92, 12, 8010–8014 (2020)
4. Olga O. Krasnovskaya, Dmitry A. Guk, Alexey E. Naumov, Vita N. Nikitina, Alevtina S. Semkina, Kseniya Yu. Vlasova, Vadim Pokrovsky, Oksana O. Ryabaya, Saida S. Karshieva, Dmitry A. Skvortsov, Irina V. Zhirkina, Radik R. Shafikov, Petr V. Gorelkin, Alexander N. Vaneev, Alexander S. Erofeev, Dmitrii M. Mazur, Viktor A. Tafeenko, Vladimir I. Pergushov, Mikhail Ya. Melnikov, Mikhail A. Soldatov, Victor V. Shapovalov, Alexander V. Soldatov, Roman. A. Akasov, Vasily M. Gerasimov, Dmitry A. Sakharov, Anna A. Moiseeva, Nikolay V. Zyk, Elena K. Beloglazkina, and Alexander G. Majouga, Novel Copper-Containing Cytotoxic Agents Based on 2-Thioxoimidazolones, Journal of Medicinal Chemistry 63, 21, 13031–13063 (2020)
5. Anna Alova, Alexander Erofeev, Petr Gorelkin, Tatyana Bibikova, Yury Korchev, Alexander Majouga, Alexander Bulychev, Prolonged oxygen depletion in microwounded cells of Chara corallina detected with novel oxygen nanosensors, Journal of Experimental Botany, 71, 1, 386–398 (2020)
6. Maria Medvedeva, Kseniya Barinova, Aleksandra Melnikova, Pavel Semenyuk, Vasillii Kolmogorov, Petr Gorelkin, Alexander Erofeev, Vladimir Muronetz, Naturally occurring cinnamic acid derivatives prevent amyloid transformation of alpha-synuclein. Biochimie, 170, 128-139 (2020)
7. Zhang, Y., Takahashi, Y., Hong, S.P. et al. High-resolution label-free 3D mapping of extracellular pH of single living cells. Nature Communications 10, 5610 (2019)
8. A. Erofeev, P. Gorelkin, A. Garanina, A. Alova, M. Efremova, N. Vorobyeva, C. Edwards, Y Korchev, A Majouga, Novel method for rapid toxicity screening of magnetic nanoparticles, Scientific Reports volume 8, 7462 (2018)
9. Pershina Alexandra G., Brikunova Olga Ya, Demin Alexander M., Abakumov Maxim A., Vaneev Alexander N., Naumenko Victor A., Erofeev Alexander S., Gorelkin Peter V., Nizamov Timur R., Muslimov Albert R., Timin Alexander S., Malkeyeva Dina, Kiseleva Elena, Vtorushin Sergey V., Larionova Irina V., Gereng Elena A., Minin Artem S., Murzakaev Aidar M., Krasnov Victor P., Majouga Alexander G., Ogorodova Ludmila M., Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine, volume 32, (2020)
10. Akasov R.A., Sholina N.V., Khochenkov D.A., Alova A.V., Gorelkin P.V., Erofeev A.S., Generalova A.N., Khaydukov E.V., Photodynamic therapy of melanoma by blue-light photoactivation of flavin mononucleotide. Scientific reports, volume 9, № 1 (2019)
11. Svetlana N. Pleskova Ruslan N. Kriukov Sergey Z. Bobyk Alexey V. Boryakov Peter V. Gorelkin Alexander S. Erofeev, Conditioning adhesive contacts between the neutrophils and the endotheliocytes by Staphylococcus aureus. Journal of Molecular Recognition, volume 33(9), e2846 (2020)
